Evaluation of the antimicrobial and cytotoxic effect of Dendranthemaindicum (L Desmoul ) leave extract
Abstract
Hexane, chloroform, ethyl acetate and ethanol extracts of Dendranthema indicum leaf were
studied for their cytotoxic effect and antimicrobial activities against seven human pathogenic
bacteria Shigella dysenteriae, Salmonella typhi, klebsiella pneumonia, Staphylococcus aureus,
proteus mirabilis, Escericia coli and pseudomonas aeriginosa,) using disc diffusion method.
All the extracts exhibited moderate to good antibacterial activity against all the pathogens
tested except proteus mirabilis and Salmonella typhi, The chloroform extract exhibited the
largest zone of inhibition (20 mm) against Staphylococcus aureus.The ethyl acetate extracts
exhibited the highest lethality on brine shrimp larvae at LC 50 values 211.6. (LC 50 ) were
determined at 95% confidence intervals by analyzing the data on a computer loaded with
“Finney Programme.”
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