Biochemical activities of Curcuminoid analogues with Methyl substituted phenyl ring and their Transition metal chelates
Abstract
In recent years there has been an increased enthusiasm in treating the diseases by natural
products.Curcumin has found a wide application in this context.Curcumin and its analogues have been
extensively studied for their biological activities including antimicrobial,antiinflammatory,antioxidant,anticarcinogenic etc. Recently a number of compounds structurally related to
curcuminoids were synthesized and their chemotherapeutic potential has been revealed. In the present study, the
synthesis and characterization of two curcuminoid analogues with methyl substituted phenyl ring and their
metal chelates Cu(II),Zn(II),Oxovanadium(IV)&Ni(II) are discussed here. The curcuminoid analogues
namely 1,7-bis(2-methyl phenyl)hepta-1,6-diene-3,5-dione(L1) and 1,7-bis(2,5-dimethyl phenyl)hepta-1,6-
diene-3,5-dione(L2) and their metal chelates were synthesized and were characterized using UV, IR, 1H NMR
and mass spectral data. In vitro cytotoxic studies were done with ligands and metal complexes against EAC
cells(Ehrilch Ascites Carcinoma) using Trypan blue exclusion method and antibacterial study of the compounds
were done using agar well diffusion method. The in vivo antitumour activity of the ligand and complexes were
determined by using DLA cells(Daltons Lymphoma Ascites) in mice and compared with standard anticancer
drug cyclophosphamide. The life spans of the treated animals were increased. The present investigation reveals
that the Cu(II) complexes show enhanced cytotoxic activity and antibacterial activity than the curcuminoid
analogues ,Zn(II),Ni(II) and Oxovanadium(IV) complex.
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References
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