Evaluation of changes in liver functions of normal pregnant women in Shendi locality, Sudan
Abstract
Changes in value of certain serum liver function tests occur during normal
pregnancy and an understanding of these physiological changes is necessary for the management
of liver diseases.
Material & Methods: This cross-sectional study was conducted at Shendi locality. The
patients underwent a clinical assessment, which included history (a questionnaire) and clinical
examination. 160 women were divided into four group’s non pregnant as control group, 1st, 2nd
and 3rd trimester of pregnancy respectively. The age limits was 12 to 40 years. Serum sample was
taken and assessed for routine liver function tests.
Results: All values were within normal limits. Serum ALT and AST activity was slightly
decreased (not significant) in first, second and third trimester than control pregnant women. The
mean value of serum total, direct and in direct bilirubin concentrations were also slightly
decreased (not significant) in first and second trimester than control but increased third
trimester pregnant women.
Conclusion:
It concluded that the serum ALT, AST and total bilirubin are affected by pregnancy in the3rd
trimester more than the1st trimester.
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