Phytochemical studies, antimicrobial and antituberculosis evaluation of extracts from the stem bark of Psorospermum senegalense(Spach)

  • Momoh, H
  • Dambata, M.B Federal University Gusau Zamfara-Nigeria
  • Tahir, M.T Federal University Dutse Jigawa-Nigeria
DOI: https://doi.org/10.53555/as.v3i6.1292
Keywords: Psorospermum senegalense, phytochemical,, antimicrobial,, antituberculosis activity,, Mycobacterium bovis,, BCG.

Abstract

Psorospermum senegalense which is traditionally used in the treatment of tuberclosis (TB) in
Northern Nigeria was investigated. Phytochemical analysis revealed the presence of flavonoids,
carbohydrates, cardiac glycosides, steroids, triterpenes, alkaloids, tannins and saponins.
Preliminary antimicrobial studies, showed that the ethyl acetate (EA) extract showed the highest
zone of inhibition (ZI) ranging from 25 to 31 mm on the test organism. The hexane (HE),
dichloromethane (DCM) and methanol extract showed ZI ranging from 18-21, 20- 27 and 20-24
mm on the test organism respectively. The results of the minimum inhibitory concentration
(MIC) determination shows that EA inhibited all the test organism at a low concentration of 7.5
mg/mL except for Pseudomonas aeruginosa (PA) and Candida albican (CA) which showed an
MIC of 15 mg/mL. On Mycobacterium bovis (BCG) an MIC of 2.5 mg/mL was observed for
EA, while other extracts did not show activity.

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Author Biographies

Momoh, H

Department of Chemistry,

Dambata, M.B, Federal University Gusau Zamfara-Nigeria

Department of Chemistry

Tahir, M.T, Federal University Dutse Jigawa-Nigeria

Department of Chemistry,

Published
2017-06-30
How to Cite
H, M., M.B, D., & M.T, T. (2017). Phytochemical studies, antimicrobial and antituberculosis evaluation of extracts from the stem bark of Psorospermum senegalense(Spach). IJRDO-Journal of Applied Science, 3(6), 01-11. https://doi.org/10.53555/as.v3i6.1292
Issue
Vol. 3 No. 6 (2017): IJRDO - Journal of Applied Science
Section
Articles

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